They are concerned for the future of their businesses as parking and delivery space will be further limited on the street, which was severely affected by infrastructure work five years ago.
The operation will target 1,000 businesses, and those who do not comply can face fines.
With the city facing ever more glaring needs as it prepares for winter during the pandemic, Montreal's mayor welcomed a deal between Quebec and Ottawa to finance social housing. But new projects are years away from fruition.
Deputy Premier Geneviève Guilbault is expected to announce new enforcement measures to ensure Quebecers are following public health guidelines later this morning.